Fibrosis-4 (FIB-4) Index for Liver Fibrosis

Noninvasive estimate of liver scarring in HCV and HBV patients, to assess need for biopsy.

Instructions

ADVICE

Low fibrosis scores may be appropriate candidates for medical management and may not require liver biopsy if FIB-4 scores continue to stay low.
Severe fibrosis/cirrhosis scores may need liver biopsy for confirmation of cirrhosis unless there are other clinical or imaging signs of progression to end-stage liver disease.

Age *

Use with caution in patients <35 or >65 years old, as the score has been shown to be less reliable in these patients

years

AST *

Aspartate aminotransferase

U/L

ALT *

Alanine aminotransferase

U/L

Platelet count *

Result

Fibrosis-4 (FIB-4) Index for Liver Fibrosis

Step-by-step mode. Answer each question and result updates automatically.

Questions

1 Age

2 AST

3 ALT

4 Platelet count

Step 1 of 4 25%

Age *

Step 1 of 4

years

AST *

Step 2 of 4

U/L

ALT *

Step 3 of 4

U/L

Platelet count *

Step 4 of 4

Sterling RK, Lissen E, Clumeck N, et al. Development of a simple noninvasive index to predict significant fibrosis in patients with HIV/HCV coinfection. Hepatology. 2006;43(6):1317-1325.
Vallet-Pichard A, Mallet V, Nalpas B, et al. FIB-4: an inexpensive and accurate marker of fibrosis in HCV infection. Comparison with liver biopsy and fibrotest. Hepatology. 2007;46(1):32-36.

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Fibrosis-4 (FIB-4) Index for Liver Fibrosis

All questions complete

Fibrosis-4 (FIB-4) Index for Liver Fibrosis

Age *

AST *

ALT *

Platelet count *

All questions complete

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